Publication  

DOI  

Application   

Journal  

Year  

Weiermair et al. (2024). Implementation and validation of a UHPLC-MS/MS method for quantification of the endocannabinoids AEA and 2-AG in cerebral interstitial fluid and plasma. Journal of Pharmaceutical and Biomedical Analysis 238: 115844.  

https://doi.org/10.1016/j.jpba.2023.115844 

cOFM 

Journal of Pharmaceutical and Biomedical Analysis 

2024 

Altendorfer-Kroath et al. (2023). In vivo monitoring of brain pharmacokinetics and pharmacodynamics with cerebral open flow microperfusion. Biopharmaceutics and Drug Disposition 44( 1): 84– 93  

https://doi.org/10.1002/bdd.2343  

cOFM   

Biopharmaceutics & Drug Disposition  

2023 

Altendorfer-Kroath, et al. (2023) Atraumatic access to human glioblastoma in a xenograft animal model by cerebral open flow microperfusion, Journal of Neuroscience Methods 393: 109893.  

https://doi.org/10.1016/j.jneumeth.2023.109893  

cOFM and glioblastoma xenograft   

Journal of Neuroscience Methods   

2023 

Schwaggerle et al. (2023). Detailed pharmacokinetic characterization of advanced topical acyclovir formulations with IVPT and in vivo Open Flow Microperfusion. International Journal of Pharmaceuticals 643(25): 123269.  

https://doi.org/10.1016/j.ijpharm.2023.123269 

dOFM and pigs 

International Journal of Pharmaceutics 

2023 

Altendorfer-Kroath et al. (2023). Quantification of the therapetic antibody Ocrelizumab in mouse brain interstitual fluid using Open Flow Microperfusion and simultaneous monitoring of the blood brain barrier. Pharmaceutics 15(7): 1880.  

https://doi.org/10.3390/pharmaceutics15071880 

cOFM 

Pharmaceutics  

2023 

Birngruber et al. (2023). Topical delivery systems effectively transport analgesics to areas of localized pain via direct diffusion. Pharmaceutics 15911): 2563 

https://doi.org/10.3390/pharmaceutics15112563 

dOFM 

Pharmaceutics  

2023 

KreB et al. (2022) Innovative Platform for the Advanced Online Monitoring of Three-Dimensional Cells and Tissue Cultures. Cells 11(3): 412.  

https://doi.org/10.3390/cells11030412  

OFM probe integrated in a 3D cell culture  

Cells  

2022 

Holzer-Geissler et al. (2022). The impact of prolonged inflammation on wound healing. Biomedicines 10(4): 856.  

https://doi.org/10.3390/biomedicines10040856 

dOGM and pigs 

Biomedicines  

2022 

Custers et al. (2022). Current Approaches to Monitor Macromolecules Directly from the Cerebral Interstitial Fluid. Pharmaceutics 14(5): 1051.  

https://doi.org/10.3390/pharmaceutics14051051  

cOFM  

Pharmaceutics  

2022 

Birngruber et al. (2022). Dermal open flow microperfusion for PK-based clinical bioequivalence studies of topical drug products. Frontiers in Pharmacology 13: 1061178  

https://doi.org/10.3389/fphar.2022.1061178  

dOFM   

Frontiers in Pharmacology  

2022 

Hummer et al. (2020)  OFM-recirculation and OFM-suction: advanced in-vivo open flow microperfusion (OFM) methods for direct and absolute quantification of albumin in interstitial fluid. Biomedical Physics & Engineering Express 6: 065031.  

https://doi.org/10.1088/2057-1976/abc3a7   

dOFM in pigs   

Biomedical Physics & Engineering Express  

2021 

Yang et al. (2021). A novel minimally invasive OFM technique with orthotopic transplantation of hUC-MSCs and in vivo monitoring of liver metabolic microenvironment in liver fibrosis treatment. Stem Cell Research & Therapy 12: 534   

https://doi.org/10.1186/s13287-021-02599-w  

OFM transplantation of hUC-MSCs for treatment of liver fibrosis  

Stem Cell Research & Therapy  

2021 

Stangler et al. (2021)Microdialysis and microperfusion electrodes in neurologic disease monitoring. Fluids Barriers CNS 18: 52.  

https://doi.org/10.1186/s12987-021-00292-x  

cOFM and icrodialysis  

Fluids and Barriers of the CNS  

2021 

Le Prieult et al. (2021) Collecting antibodies and large molecule biomarkers in mouse interstitial brain fluid: a comparison of microdialysis and cerebral open flow microperfusion, mAbs 13:1.  

https://doi.org/10.1080/19420862.2021.1918819  

cOFM and microdialysis  

mAbs  

2021 

Custers et al. (2020) Applicability of cerebral open flow microperfusion and microdialysis to quantify a brain-penetrating nanobody in mice, Analytica Chimica Acta, Volume 1178(15): 338803.  

https://doi.org/10.1016/j.aca.2021.338803  

cOFM and microdialysis  

Analytica Chimica Acta  

2021 

Altendorfer-Kroath et al. (2019) Comparison of cerebral Open Flow Microperfusion and Microdialysis when sampling small lipophilic and small hydrophilic substances. Journal of Neuroscience Methods 311, 2019: 394-401.  

https://doi.org/10.1016/j.jneumeth.2018.09.024  

cOFM and microdialysis  

Journal of Neuroscience Methods   

2019 

Kleinert et al. (2018). Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood–brain barrier in leptin resistant mice. Molecular Metabolism 13: 77-82.  

https://doi.org/10.1016/j.molmet.2018.04.008  

cOFM  

Molecular Metabolism  

2018 

Bodenlenz et al. (2017). Open Flow Microperfusion as a Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence. Clinical Pharmacokinetics 56: 91–98.  

https://doi.org/10.1007/s40262-016-0442-z   

dOFM  

Clinical Pharmacokinetics  

2017 

Bodenlenz et al. (2016). Kinetics of Clobetasol-17-Propionate in Psoriatic Lesional and Non-Lesional Skin Assessed by Dermal Open Flow Microperfusion with Time and Space Resolution. Pharmaceutical Research 33(9): 2229–2238.  

https://doi.org/10.1007/s11095-016-1960-y   

dOFM   

Pharmaceutical Research  

2016 

Dragatin et al. (2016). Secukinumab distributes into dermal interstitial fluid of psoriasis patients as demonstrated by open flow microperfusion. Dragatin et al. Experimental Dermatology 25(2): 151-164.  

https://doi.org/10.1111/exd.12863   

dOFM  

Experimental Dermatology  

2016 

Jadhav, et al.(2016). Microdialysis of Large Molecules, Journal of Pharmaceutical Sciences 105(11): P3233-3242.  

DOI:https://doi.org/10.1016/j.xphs.2016.08.016  

Microdialysis  

Journal of Pharmaceutical Sciences  

2016 

Birngruber & Sinner (2016). Cerebral open flow microperfusion (cOFM) an innovative interface to brain tissue. Drug Discovery Today: Technologies 20: 19-25.   

https://doi.org/10.1016/j.ddtec.2016.07.003  

cOFM  

Drug Discovery Today  

2016 

Birngruber et al. (2014). Long-Term Implanted cOFM Probe Causes Minimal Tissue Reaction in the Brain. PLoS ONE 9(3): e90221.  

https://doi.org/10.1371/journal.pone.0090221  

cOFM  

PLoS ONE  

2014 

Ghosh et al. (2014). Assessment of Blood-Brain Barrier Function and the Neuroinflammatory Response in the Rat Brain by Using Cerebral Open Flow Microperfusion (cOFM). PLoS ONE 9(5): e98143.   

https://doi.org/10.1371/journal.pone.0098143  

cOFM  

PLoS ONE  

2014 

Birngruber, et al. (2014). Enhanced Doxorubicin Delivery to the Brain Administered Through Glutathione PEGylated Liposomal Doxorubicin (2B3-101) as Compared with Generic Caelyx,®/Doxil®—A Cerebral Open Flow Microperfusion Pilot Study. Journal of Pharmaceutical Sciences 103(7):P1945-1948.  

https://doi.org/10.1002/jps.23994  

cOFM   

Journal of Pharmaceutical Sciences  

2014 

Holmgaard et al. (2012). Comparison of Open-Flow Microperfusion and Microdialysis Methodologies When Sampling Topically Applied Fentanyl and Benzoic Acid in Human Dermis Ex Vivo. Pharmaceutical Research 29: 1808-1820.   

http://dx.doi.org/10.1007/s11095-012-0705-9  

dOFM and microdialysis  

Pharmaceutical Research  

2012 

Pickl et al. (2007) Rapid online-SPE-MS/MS method for ketoprofen determination in dermal interstitial fluid samples from rats obtained by microdialysis or open-flow microperfusion, Journal of Chromatography B 850(1–2): 432-439.  

https://doi.org/10.1016/j.jchromb.2006.12.026  

dOFM and microdialysis  

Journal of Chromatography B  

2007